Unexpected substituent effect in the stereoselective synthesis of trifluoromethyl group containing cyclopropane lactones

被引：4

作者：

Faigl, F ^{[1
]}

Finta, Z

Hell, Z

Kövesdi, I

Toke, L

机构：

[1] Tech Univ Budapest, Dept Organ Chem Technol, H-1521 Budapest, Hungary

[2] EGIS Pharmaceut Works Co, H-1106 Budapest, Hungary

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2000年 / 103卷 / 02期

基金：

匈牙利科学研究基金会; 新加坡国家研究基金会;

关键词：

trifluoromethyl group effect; stereoselective synthesis; cyclopropane derivatives;

D O I：

10.1016/S0022-1139(99)00309-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Methyl or phenyl substitution in the allylic position of malonic esters of (E)-3-phenyl-3-trifluoromethyI-2-propen-1-ol resulted in unexpected and unprecedented stereospecific formation of the corresponding cyclopropane lactone derivatives by a multistep reaction with iodine in the presence of potassium carbonate and phase transfer catalyst. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：117 / 121

页数：5

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