Is there a role for polyenes in treating invasive mycoses?

被引:14
作者
Cornely, Oliver A. [1 ]
Vehreschild, Joerg-Janne [1 ]
Ullmann, Andrew J. [1 ]
机构
[1] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany
关键词
amphotericin B deoxycholate; amphotericin B lipid complex; aspergillosis; candidiasis; liposomal amphotericin B; polyene;
D O I
10.1097/QCO.0b013e328010851d
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Purpose of review This is a clinical review on the current role of polyene antifungals in the treatment of invasive fungal infections. It is timely and relevant because the number of new antifungals being developed has never been greater than today. In addition to re-examining the landmark clinical trials of the past, the more recent findings are put into perspective. The past year has been particularly rich in clinical trials. Recent findings The main topics of this review are invasive candidiasis, invasive aspergillosis, and the so-called rare fungal infections: zygomycosis, fusariosis, cryptococcosis and histoplasmosis. Summary Practical implications of the recent developments are the almost complete replacement of amphotericin B deoxycholate by lipid based formulations; antifungal efficacy without compromising safety; and treatment choices for infections previously considered untreatable.
引用
收藏
页码:565 / 570
页数:6
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