Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470

被引：163

作者：

Klauber, N

Rohan, RM

Flynn, E

DAmato, RJ

机构：

[1] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT SURG,BOSTON,MA 02115

[2] BOSTON UNIV,MED CTR,DEPT SURG,BOSTON,MA 02118

来源：

NATURE MEDICINE | 1997年 / 3卷 / 04期

关键词：

D O I：

10.1038/nm0497-443

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiogenesis, the growth of new blood vessels, occurs normally in female reproductive organs. We tested the hypothesis that angiogenesis inhibition may affect fertility by studying the reproductive system in either pregnant or nonpregnant cycling mice after treatment with the angiogenesis inhibitor AGM-1470. Administration of AGM-1470 to pregnant mice resulted in complete failure of embryonic growth due to interference with decidualization, placental and yolk sac formation, and embryonic vascular development. When nonpregnant cycling female mice were chronically treated with AGM-1470, inhibition of endometrial maturation and corpora lutea was observed. These data suggest that processes in reproduction can be controlled through angiogenesis inhibition.

引用

页码：443 / 446

页数：4

共 13 条

[1] DETERMINING STAGE OF ESTROUS-CYCLE IN MOUSE BY APPEARANCE OF VAGINA [J].