LAB: A new membrane-associated adaptor molecule in B cell activation

被引：131

作者：

Janssen, E

Zhu, MH

Zhang, WJ ^{[1
]}

Koonpaew, S

Zhang, WG

机构：

[1] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA

[2] Harvard Univ, Sch Med, Div Genet, Dept Med, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 02期

关键词：

D O I：

10.1038/ni882

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation and development; a similar molecule in B cells has not yet been identified. Here, we report the identification of a new adaptor protein, linker for activation of B cells (LAB). Like LAT, LAB was localized to lipid rafts. Upon activation via the B cell receptor (BCR), LAB was phosphorylated and interacted with the adaptor protein Grb2. Decreased LAB expression led to a reduction in BCR-mediated calcium flux and Erk activation. LAB rescued thymocyte development but not normal T cell activation in LAT(-/-) mice. Our data suggest that LAB links BCR engagement to downstream signaling pathways.

引用

页码：117 / 123

页数：7

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