Hormesis: A Conversation with a Critic

被引：18

作者：

Calabrese, Edward J. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Publ Hlth, Environm Hlth Sci Div, Amherst, MA 01003 USA

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2009年 / 117卷 / 09期

关键词：

adaptive response; biphasic; dose response; hormesis; hormetic; linear dose response; risk assessment; threshold dose response; U-shaped; HORMETIC DOSE RESPONSES; THRESHOLD-MODEL; CONFIDENCE-INTERVALS; TOXICOLOGY; INFERENCE; DATABASE; BECAME; EYE;

D O I：

10.1289/ehp.0901002

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

OBJECTIVE: In this commentary I respond to points raised in the commentary by Mushak [Ad hoc and fast forward: the science and control of hormesis growth and development. Environ Health Perspect 117:1333-1338 (2009)], which principally concerns studies by me and my colleagues concerning the frequency of hormesis in toxicology. DISCUSSION: In this commentary I demonstrate that Mushak's analysis contains critical statistical errors and misunderstandings of statistical concepts that invalidate its conclusions concerning the frequency of hormesis in the toxicologic literature. CONCLUSIONS: In his commentary Mushak offers no significant new conceptual insights, and his key technical criticisms of hormesis frequency findings are unfounded.

引用

页码：1339 / 1343

页数：5

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