Adult-Type Granulosa Cell Tumors and FOXL2 Mutation

被引：51

作者：

Koebel, Martin ^{[2
]}

Gilks, C. Blake ^{[3
]}

Huntsman, David G. ^{[1
]}

机构：

[1] British Columbia Canc Agcy, Ctr Translat & Appl Genom, Vancouver, BC V5Z 4E6, Canada

[2] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB T2N 1N4, Canada

[3] Vancouver Gen Hosp, Dept Pathol, Genet Pathol Evaluat Ctr Prostate Res Ctr, Vancouver, BC, Canada

来源：

CANCER RESEARCH | 2009年 / 69卷 / 24期

基金：

加拿大健康研究院;

关键词：

TRANSCRIPTION FACTOR FOXL2; OVARY; EXPRESSION; PROTEIN;

D O I：

10.1158/0008-5472.CAN-09-2669

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Little is known about the pathogenesis of ovarian granulosa cell tumors. Recently, we reported the identification of a somatic FOXL2 402C -> G mutation that is present in virtually all adult-type granulosa cell tumors, but not in a wide range of other tumor types. This finding has important implications for the diagnosis and classification of ovarian sex cord-stromal tumors, provides insight into the pathogenesis of adult-type granulosa cell tumors, and opens possibilities for the development of targeted therapies. [Cancer Res 2009;69(24):9160-2]

引用

页码：9160 / 9162

页数：3

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