Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum

被引：143

作者：

Guo, Liang ^{[2
,3
]}

Xie, Jianhui ^{[2
,3
]}

Ruan, Yuanyuan ^{[2
,3
]}

Zhou, Lei ^{[2
,3
]}

Zhu, Haiyan ^{[2
,3
]}

Yun, Xiaojing ^{[2
,3
]}

Jiang, Yan ^{[4
]}

Lue, Long ^{[4
]}

Chen, Kangli ^{[2
,3
]}

Min, Zhihui ^{[5
]}

Wen, Yumei ^{[1
]}

Gu, Jianxin ^{[2
,3
]}

机构：

[1] Fudan Univ, Key Lab Med Mol Virol, Shanghai Med Coll, Inst Med Microbiol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Ctr Gene Res, Shanghai Med Coll, Shanghai 200032, Peoples R China

[3] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[5] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Beijing 100864, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2009年 / 9卷 / 10期

关键词：

Anti-tumor; Glucan; Dectin-1; Ganoderma lucidum; Spores; BINDING LECTIN SITE; BETA-GLUCANS; PATTERN-RECOGNITION; CR3; CD11B/CD18; IMMUNE-SYSTEM; DECTIN-1; MACROPHAGES; RECEPTOR; MECHANISMS; FUNGAL;

D O I：

10.1016/j.intimp.2009.06.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Spores of Ganoderma lucidum contain a large amount of bioactive substances and have a higher bioactivity than the fruit bodies of G. lucidum. However, ingredients from spores are less studied due to the difficulties in collecting the spores and breaking the rigid shell. In this study, a water-soluble polysaccharide named GSG was extracted from the spores of G. lucidum. GSG is characterized to be a branched glucan that contains several different kinds of linkages. It was an effective inducer of MAPKs- and Syk-dependent TNF-alpha and IL-6 secretion in murine resident peritoneal macrophages. Dectin-1 could recognize GSG and partially mediate its biological activities. Additionally, in vivo administration of GSG potentiated the Con A-induced proliferative response of splenocytes and induced anti-tumor activity against Lewis lung cancer in mice. Therefore, these results suggest that GSG is an effective immunomodulator and may be a promising adjuvant remedy for antitumor therapies. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1175 / 1182

页数：8

共 39 条

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