Analysis of the β-tubulin genes from Enterocytozoon bieneusi isolates from a human and rhesus macaque

被引:26
作者
Akiyoshi, Donna E. [1 ]
Weiss, Louis M.
Feng, Xiaochuan
Williams, Bryony A. P.
Keeling, Patrick J.
Zhang, Quanshun
Tzipori, Saul
机构
[1] Tufts Cummings Sch Vet Med, Div Infect Dis, North Grafton, MA 01536 USA
[2] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA
[3] Univ British Columbia, Dept Bot, Canadian Inst Adv Res, Vancouver, BC V6T 1Z4, Canada
关键词
albendazole resistance; beta-tubulin gene; microsporidia;
D O I
10.1111/j.1550-7408.2006.00140.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Enterocytozoon bieneusi is the most common and clinically significant microsporidium associated with chronic diarrhea and wasting in immunocompromised humans. Albendazole, which is effective against several helminths, protozoa, and microsporidia, is relatively ineffective against infections due to E. bieneusi. A likely explanation for the observed clinical resistance to albendazole was discovered from sequence analysis of the E. bieneusi beta-tubulin from isolates from an infected human and a naturally infected rhesus macaque. The beta-tubulin of E. bieneusi has a substitution at Glu(198), which is one of six amino acids reported to be associated with benzimidazole sensitivity.
引用
收藏
页码:38 / 41
页数:4
相关论文
共 44 条
[1]   Enterocytozoon bieneusi infection in patients who are not infected with human immunodeficiency virus [J].
Albrecht, H ;
Sobottka, I .
CLINICAL INFECTIOUS DISEASES, 1997, 25 (02) :344-344
[2]   BASIC LOCAL ALIGNMENT SEARCH TOOL [J].
ALTSCHUL, SF ;
GISH, W ;
MILLER, W ;
MYERS, EW ;
LIPMAN, DJ .
JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) :403-410
[3]   THE PREVALENCE OF INVASIVE AMEBIASIS IS NOT INCREASED IN PATIENTS WITH AIDS [J].
JESSURUN, J ;
BARRONRODRIGUEZ, LP ;
FERNANDEZTINOCO, G ;
HERNANDEZAVILA, M .
AIDS, 1992, 6 (03) :307-309
[4]  
CALI A, 1991, J PROTOZOOL, V38, P625
[5]   Therapy for human gastrointestinal microsporidiosis [J].
Conteas, CN ;
Berlin, OGW ;
Ash, LR ;
Pruthi, JS .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2000, 63 (3-4) :121-127
[6]   IN-VITRO SUSCEPTIBILITY OF THE OPPORTUNISTIC FUNGUS CRYPTOCOCCUS-NEOFORMANS TO ANTHELMINTIC BENZIMIDAZOLES [J].
CRUZ, MC ;
BARTLETT, MS ;
EDLIND, TD .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (02) :378-380
[7]   HUMAN MICROSPORIDIOSIS [J].
CURRY, A ;
CANNING, EU .
JOURNAL OF INFECTION, 1993, 27 (03) :229-236
[8]   BENZIMIDAZOLE FUNGICIDES - MECHANISM OF ACTION AND BIOLOGICAL IMPACT [J].
DAVIDSE, LC .
ANNUAL REVIEW OF PHYTOPATHOLOGY, 1986, 24 :43-65
[9]   POLYMERASE CHAIN-REACTION AND CULTURE CONFIRMATION OF DISSEMINATED ENCEPHALITOZOON-CUNICULI IN A PATIENT WITH AIDS - SUCCESSFUL THERAPY WITH ALBENDAZOLE [J].
DEGROOTE, MA ;
VISVESVARA, G ;
WILSON, ML ;
PIENIAZEK, NJ ;
SLEMENDA, SB ;
DASILVA, AJ ;
LEITCH, GJ ;
BRYAN, RT ;
REVES, R .
JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (05) :1375-1378
[10]   Epidemiology of microsporidiosis: sources and modes of transmission [J].
Didier, ES ;
Stovall, ME ;
Green, LC ;
Brindley, PJ ;
Sestak, K ;
Didier, P .
VETERINARY PARASITOLOGY, 2004, 126 (1-2) :145-166