Design of a capillary-microreactor for efficient Suzuki coupling reactions

被引：38

作者：

Basheer, C ^{[1
]}

Shahitha, F ^{[1
]}

Hussain, J ^{[1
]}

Lee, HK ^{[1
]}

Valiyaveettil, S ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 39期

关键词：

microreactors; reaction engineering; Suzuki coupling; microfluidics;

D O I：

10.1016/j.tetlet.2004.08.017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pyrex glass capillary (0.4mm internal diameter) microreactor was developed and used for Suzuki coupling reactions. Capillary-microreactors are more attractive than photolithographic microfluidic devices in terms of simplicity, low cost and ease of handling. Compared with the conventional synthesis procedure, our approach of using a capillary-micro reactor offers a convenient and highly efficient means to optimize reaction conditions and the performance of catalysts. The procedure exhibits good precision, reproducibility and high reaction yield for a range of reactants investigated. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7297 / 7300

页数：4

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