Biometrical genetics

被引:107
作者
Evans, DM
Gillespie, NA
Martin, NG
机构
[1] Univ Queensland, Queensland Inst Med Res, Brisbane, Qld 4029, Australia
[2] Univ Queensland, Joint Genet Program, Brisbane, Qld 4029, Australia
关键词
structural equation modeling; genetics; Mendelian principles; twin studies;
D O I
10.1016/S0301-0511(02)00051-0
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Biometrical genetics is the science concerned with the inheritance of quantitative traits. In this review we discuss how the analytical methods of biometrical genetics are based upon simple Mendelian principles. We demonstrate how the phenotypic covariance between related individuals provides information on the relative importance of genetic and environmental factors influencing that trait, and how factors such as assortative mating, gene-environment correlation and genotype-environment interaction complicate such interpretations. Twin and adoption studies are discussed as well as their assumptions and limitations. Structural equation modeling (SEM) is introduced and we illustrate how this approach may be applied to genetic problems. In particular, we show how SEM can be used to address complicated issues such as analyzing the causes of correlation between traits or determining the direction of causation (DOC) between variables. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:33 / 51
页数:19
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