IGF and insulin action in the mammary gland: Lessons from transgenic and knockout models

被引：68

作者：

Hadsell, DL ^{[1
]}

Bonnette, SG ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, USDA ARS, Houston, TX 77030 USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2000年 / 5卷 / 01期

关键词：

insulin; transgenic; knockout; mammary; IGF;

D O I：

10.1023/A:1009559014703

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transgenic and knockout mice have become valuable experimental systems with which to study specific molecular events within the mammary gland of an intact animal. These models have provided a wealth of information about the effects of a number of oncogenes and growth Factors. This review focuses on results obtained From the application of transgenic and knockout models to determine the roles of insulin and insulin-like growth factors (ICF)(3) in the regulation of mammary gland development, lactation and tumorigenesis. Transgenic models which overexpress IGF-I or -II display specific alterations in mammary gland development and an increased incidence of mammary tumors. Analysis of mammary gland development in knockout mice which are deficient in IGF-I or the IGF-I receptor supports the conclusion that the IGF system is important for normal mammary gland development. This review discusses these observations in detail and attempts to Fit them into a larger picture of IGF and insulin action in the mammary gland.

引用

页码：19 / 30

页数：12

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