共 44 条
P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin
被引:65
作者:

Hirata, T
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Ctr Hemostasis & Thrombosis Res, Boston, MA 02215 USA

Furie, BC
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Ctr Hemostasis & Thrombosis Res, Boston, MA 02215 USA

Furie, B
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Ctr Hemostasis & Thrombosis Res, Boston, MA 02215 USA
机构:
[1] Beth Israel Deaconess Med Ctr, Ctr Hemostasis & Thrombosis Res, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
关键词:
D O I:
10.4049/jimmunol.169.8.4307
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
P- and E-selectin mediate CD4(+) Th1 cell migration into the inflamed skin in a murine contact hypersensitivity model. In this model, not only CD4(+) T cells but also CD8(+) T cells infiltrate the inflamed skin, and the role of CD8(+) type 1 cytotoxic T (Tc1) cells as effector cells has been demonstrated. Here we show that in mice deficient in both P- and E-selectin, the infiltration of CD8(+) T cells in the inflamed skin is reduced, suggesting the role of these selectins in CD8(+) T cell migration. We directly studied the role of selectins using in vitro-generated Tc1 cells. These cells are able to migrate into the inflamed skin of wild-type mice. This migration is partially mediated by P- and E-selectin, as shown by the reduced Tc1 cell migration into the inflamed skin of mice deficient in both P- and E-selectin or wild-type mice treated with the combination of anti-P-selectin and anti-E-selectin Abs. During P- and E-selectin-mediated migration of Tc1 cells, P-selectin glycoprotein ligand-1 appears to be the sole ligand for P-selectin and one of the ligands for E-selectin. P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly. mediated by L-selectin. These observations indicate that all three selectins can mediate Tc1 cell migration into the inflamed skin.
引用
收藏
页码:4307 / 4313
页数:7
相关论文
共 44 条
[1]
Functional diversity of helper T lymphocytes
[J].
Abbas, AK
;
Murphy, KM
;
Sher, A
.
NATURE,
1996, 383 (6603)
:787-793

Abbas, AK
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

Murphy, KM
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

Sher, A
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
[2]
THE INTEGRIN VLA-4 SUPPORTS TETHERING AND ROLLING IN FLOW ON VCAM-1
[J].
ALON, R
;
KASSNER, PD
;
CARR, MW
;
FINGER, EB
;
HEMLER, ME
;
SPRINGER, TA
.
JOURNAL OF CELL BIOLOGY,
1995, 128 (06)
:1243-1253

ALON, R
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115

KASSNER, PD
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115

CARR, MW
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115

FINGER, EB
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115

HEMLER, ME
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115

SPRINGER, TA
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115
[3]
P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
[J].
Austrup, F
;
Vestweber, D
;
Borges, E
;
Lohning, M
;
Brauer, R
;
Herz, U
;
Renz, H
;
Hallmann, R
;
Scheffold, A
;
Radbruch, A
;
Hamann, A
.
NATURE,
1997, 385 (6611)
:81-83

Austrup, F
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY

Vestweber, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY

Borges, E
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY

Lohning, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY

Brauer, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY

Herz, U
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY

Renz, H
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY

Hallmann, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY

Scheffold, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY

Radbruch, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY

Hamann, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HAMBURG, KRANKENHAUS EPPENDORF, MED KLIN, IMMUNOL ABT, D-20246 HAMBURG, GERMANY
[4]
Migration of activated CD8+ T lymphocytes to sites of viral infection does not require endothelial selectins
[J].
Bartholdy, C
;
Marker, O
;
Thomsen, AR
.
BLOOD,
2000, 95 (04)
:1362-1369

Bartholdy, C
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Copenhagen, Panum Inst, Inst Med Microbiol & Immunol, DK-2200 Copenhagen N, Denmark Univ Copenhagen, Panum Inst, Inst Med Microbiol & Immunol, DK-2200 Copenhagen N, Denmark

Marker, O
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Copenhagen, Panum Inst, Inst Med Microbiol & Immunol, DK-2200 Copenhagen N, Denmark Univ Copenhagen, Panum Inst, Inst Med Microbiol & Immunol, DK-2200 Copenhagen N, Denmark

Thomsen, AR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Copenhagen, Panum Inst, Inst Med Microbiol & Immunol, DK-2200 Copenhagen N, Denmark Univ Copenhagen, Panum Inst, Inst Med Microbiol & Immunol, DK-2200 Copenhagen N, Denmark
[5]
A method to recover, enumerate and identify lymphomyeloid cells present in an inflammatory dermal site: A study in laboratory mice
[J].
Belkaid, Y
;
Jouin, H
;
Milon, G
.
JOURNAL OF IMMUNOLOGICAL METHODS,
1996, 199 (01)
:5-25

Belkaid, Y
论文数: 0 引用数: 0
h-index: 0
机构: INST PASTEUR,UNITE IMMUNOPHYSIOL CELLULAIRE,F-75015 PARIS,FRANCE

Jouin, H
论文数: 0 引用数: 0
h-index: 0
机构: INST PASTEUR,UNITE IMMUNOPHYSIOL CELLULAIRE,F-75015 PARIS,FRANCE

Milon, G
论文数: 0 引用数: 0
h-index: 0
机构: INST PASTEUR,UNITE IMMUNOPHYSIOL CELLULAIRE,F-75015 PARIS,FRANCE
[6]
THE CUTANEOUS LYMPHOCYTE ANTIGEN IS A SKIN LYMPHOCYTE HOMING RECEPTOR FOR THE VASCULAR LECTIN ENDOTHELIAL CELL-LEUKOCYTE ADHESION MOLECULE-1
[J].
BERG, EL
;
YOSHINO, T
;
ROTT, LS
;
ROBINSON, MK
;
WARNOCK, RA
;
KISHIMOTO, TK
;
PICKER, LJ
;
BUTCHER, EC
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1991, 174 (06)
:1461-1466

BERG, EL
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,IMMUNOL & VASC BIOL LAB,STANFORD,CA 94305

YOSHINO, T
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,IMMUNOL & VASC BIOL LAB,STANFORD,CA 94305

ROTT, LS
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,IMMUNOL & VASC BIOL LAB,STANFORD,CA 94305

ROBINSON, MK
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,IMMUNOL & VASC BIOL LAB,STANFORD,CA 94305

WARNOCK, RA
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,IMMUNOL & VASC BIOL LAB,STANFORD,CA 94305

KISHIMOTO, TK
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,IMMUNOL & VASC BIOL LAB,STANFORD,CA 94305

PICKER, LJ
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,IMMUNOL & VASC BIOL LAB,STANFORD,CA 94305

BUTCHER, EC
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,IMMUNOL & VASC BIOL LAB,STANFORD,CA 94305
[7]
Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
[J].
Bonecchi, R
;
Bianchi, G
;
Bordignon, PP
;
D'Ambrosio, D
;
Lang, R
;
Borsatti, A
;
Sozzani, S
;
Allavena, P
;
Gray, PA
;
Mantovani, A
;
Sinigaglia, F
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1998, 187 (01)
:129-134

Bonecchi, R
论文数: 0 引用数: 0
h-index: 0
机构: Roche Milano Ric, I-20132 Milan, Italy

Bianchi, G
论文数: 0 引用数: 0
h-index: 0
机构: Roche Milano Ric, I-20132 Milan, Italy

Bordignon, PP
论文数: 0 引用数: 0
h-index: 0
机构: Roche Milano Ric, I-20132 Milan, Italy

D'Ambrosio, D
论文数: 0 引用数: 0
h-index: 0
机构: Roche Milano Ric, I-20132 Milan, Italy

Lang, R
论文数: 0 引用数: 0
h-index: 0
机构: Roche Milano Ric, I-20132 Milan, Italy

Borsatti, A
论文数: 0 引用数: 0
h-index: 0
机构: Roche Milano Ric, I-20132 Milan, Italy

Sozzani, S
论文数: 0 引用数: 0
h-index: 0
机构: Roche Milano Ric, I-20132 Milan, Italy

Allavena, P
论文数: 0 引用数: 0
h-index: 0
机构: Roche Milano Ric, I-20132 Milan, Italy

Gray, PA
论文数: 0 引用数: 0
h-index: 0
机构: Roche Milano Ric, I-20132 Milan, Italy

论文数: 引用数:
h-index:
机构:

Sinigaglia, F
论文数: 0 引用数: 0
h-index: 0
机构: Roche Milano Ric, I-20132 Milan, Italy
[8]
P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin
[J].
Borges, E
;
Tietz, W
;
Steegmaier, M
;
Moll, T
;
Hallmann, R
;
Hamann, A
;
Vestweber, D
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1997, 185 (03)
:573-578

Borges, E
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MUNSTER, ZMBE, INST CELL BIOL, D-48149 MUNSTER, GERMANY

Tietz, W
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MUNSTER, ZMBE, INST CELL BIOL, D-48149 MUNSTER, GERMANY

Steegmaier, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MUNSTER, ZMBE, INST CELL BIOL, D-48149 MUNSTER, GERMANY

Moll, T
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MUNSTER, ZMBE, INST CELL BIOL, D-48149 MUNSTER, GERMANY

Hallmann, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MUNSTER, ZMBE, INST CELL BIOL, D-48149 MUNSTER, GERMANY

Hamann, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MUNSTER, ZMBE, INST CELL BIOL, D-48149 MUNSTER, GERMANY

Vestweber, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MUNSTER, ZMBE, INST CELL BIOL, D-48149 MUNSTER, GERMANY
[9]
MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RESTRICTED CD8(+) T-CELLS AND CLASS II-RESTRICTED CD4(+) T-CELLS, RESPECTIVELY, MEDIATE AND REGULATE CONTACT SENSITIVITY TO DINITROFLUOROBENZENE
[J].
BOUR, H
;
PEYRON, E
;
GAUCHERAND, M
;
GARRIGUE, JL
;
DESVIGNES, C
;
KAISERLIAN, D
;
REVILLARD, JP
;
NICOLAS, JF
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
1995, 25 (11)
:3006-3010

BOUR, H
论文数: 0 引用数: 0
h-index: 0
机构: UNIV LYON 1, INSERM, U80, FAC A CARREL, F-69372 LYON 08, FRANCE

PEYRON, E
论文数: 0 引用数: 0
h-index: 0
机构: UNIV LYON 1, INSERM, U80, FAC A CARREL, F-69372 LYON 08, FRANCE

GAUCHERAND, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV LYON 1, INSERM, U80, FAC A CARREL, F-69372 LYON 08, FRANCE

GARRIGUE, JL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV LYON 1, INSERM, U80, FAC A CARREL, F-69372 LYON 08, FRANCE

DESVIGNES, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV LYON 1, INSERM, U80, FAC A CARREL, F-69372 LYON 08, FRANCE

KAISERLIAN, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV LYON 1, INSERM, U80, FAC A CARREL, F-69372 LYON 08, FRANCE

REVILLARD, JP
论文数: 0 引用数: 0
h-index: 0
机构: UNIV LYON 1, INSERM, U80, FAC A CARREL, F-69372 LYON 08, FRANCE

NICOLAS, JF
论文数: 0 引用数: 0
h-index: 0
机构: UNIV LYON 1, INSERM, U80, FAC A CARREL, F-69372 LYON 08, FRANCE
[10]
Lymphocyte homing and homeostasis
[J].
Butcher, EC
;
Picker, LJ
.
SCIENCE,
1996, 272 (5258)
:60-66

Butcher, EC
论文数: 0 引用数: 0
h-index: 0
机构: VET AFFAIRS PALO ALTO HLTH CARE SYST, CTR MOLEC BIOL & MED, PALO ALTO, CA 94304 USA

Picker, LJ
论文数: 0 引用数: 0
h-index: 0
机构: VET AFFAIRS PALO ALTO HLTH CARE SYST, CTR MOLEC BIOL & MED, PALO ALTO, CA 94304 USA