Accelerated apoptosis in SLE neutrophils cultured with anti-dsDNA antibody isolated from SLE patient serum: a pilot study

被引：14

作者：

Armstrong, David J. ^{[1
]}

Crockard, Alistair D. ^{[1
]}

Wisdom, Brian G. ^{[1
]}

Whitehead, Esme M. ^{[1
]}

Bell, Aubrey L. ^{[1
]}

机构：

[1] Musgrave Pk Hosp, Dept Rheumatol, Belfast BT9 7JB, Antrim, North Ireland

来源：

RHEUMATOLOGY INTERNATIONAL | 2006年 / 27卷 / 02期

关键词：

SLE; neutrophils; apoptosis; anti-dsDNA antibody; immunoaffinity chromatography;

D O I：

10.1007/s00296-006-0219-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Increased numbers of apoptotic neutrophils are found in SLE, related to disease activity and levels of anti-dsDNA antibody. The mechanism of increased apoptosis is not clear, but anti-dsDNA antibody has been shown to induce apoptosis in neutrophils from normal subjects and in certain cell lines. In this study, polyclonal anti-dsDNA antibody was isolated from the serum of a patient with active SLE, and was shown to substantially accelerate apoptosis in neutrophils from SLE patients as compared with neutrophils from healthy control or rheumatoid arthritis subjects.

引用

页码：153 / 156

页数：4

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