Effects of D-amphetamine on extracellular dopamine content and generation of hydroxyl radicals in the striatum of freely moving rats

被引：1

作者：

Andyarzhanova, EA ^{[1
]}

Afanas'ev, II ^{[1
]}

Kudrin, VS ^{[1
]}

Raevskii, KS ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Pharmacol, Lab Neurochem Pharmacol, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 128卷 / 11期

关键词：

D-amphetamine; dopamine; hydroxyl radicals; intracerebral microdialysis;

D O I：

10.1007/BF02433418

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Four intraperitoneal injections of D-amphetamine induced dose-dependent effects on extracellular dopamine content and generation of hydroxyl radical in rat striatum. Neurotoxic effects of D-amphetamine were probably mediated by intense generation of hydroxyl radicals.

引用

页码：1125 / 1127

页数：3

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