Kinetics of nasopharyngeal shedding of novel H1N1 (swine-like) influenza A virus in an immunocompetent adult under oseltamivir therapy

被引：7

作者：

Charlier, C. ^{[1
]}

Enouf, V. ^{[2
]}

Lanternier, F. ^{[1
]}

Grandadam, M. ^{[3
]}

Amazzough, K. ^{[1
]}

Blanche, S. ^{[4
]}

Lecuit, M. ^{[1
]}

Lortholary, O. ^{[1
]}

van der Werf, S. ^{[2
]}

机构：

[1] Univ Paris 05, Hop Necker Enfants Malad, AP HP, Ctr Infectol Necker Pasteur,Serv Malad Infect & T, F-75015 Paris, France

[2] Univ Paris 05, Natl Influenza Ctr No France, CNRS, Unite Genet Mol Virus ARN,Inst Pasteur,URA3015, F-75015 Paris, France

[3] Inst Pasteur, Unite Interact Mol Flavivirus Hotes, Paris, France

[4] Univ Paris 05, Hop Necker Enfants Malad, AP HP, Unite Hematol Immunol, F-75015 Paris, France

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2009年 / 15卷 / 12期

关键词：

Kinetics; nasal shedding; oseltamivir; PCR; swine-related influenza; UNITED-STATES; HUMANS;

D O I：

10.1111/j.1469-0691.2009.03007.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We describe a patient with confirmed novel H1N1 (swine-like) influenza A virus who had daily nasal swabs tested during oseltamivir therapy. Nasal shedding remained positive for 2 days and became negative on day 3. This report presents the first available data on the kinetics of shedding of this novel virus under antiviral therapy.

引用

页码：1189 / 1191

页数：3

共 9 条

[1]

[Anonymous], COCHRANE DATABASE SY, DOI DOI 10.1002/14651858.CD001169.PUB3

[2] Phi29 polymerase based random amplification of viral RNA as an alternative to random RT-PCR [J].

Berthet, Nicolas ;

Reinhardt, Anita K. ;

Leclercq, India ;

van Ooyen, Sven ;

Batejat, Christophe ;

Dickinson, Philip ;

Stamboliyska, Rayna ;

Old, Iain G. ;

Kong, Katherine A. ;

Dacheux, Laurent ;

Bourhy, Herve ;

Kennedy, Giulia C. ;

Korfhage, Christian ;

Cole, Stewart T. ;

Manuguerra, Jean-Claude .

BMC MOLECULAR BIOLOGY, 2008, 9

[3] Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States [J].

Bright, RA ;

Shay, DK ;

Shu, B ;

Cox, NJ ;

Klimov, AI .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (08) :891-894

[4] Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team [J].

Dawood, Fatimah S. ;

Jain, Seema ;

Finelli, Lyn ;

Shaw, Michael W. ;

Lindstrom, Stephen ;

Garten, Rebecca J. ;

Gubareva, Larisa V. ;

Xu, Xiyan ;

Bridges, Carolyn B. ;

Uyeki, Timothy M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (25) :2605-2615

[5] Prolonged Influenza Virus Infection during Lymphocytopenia and Frequent Detection of Drug-Resistant Viruses [J].

Gooskens, Jairo ;

Jonges, Marcel ;

Claas, Eric C. J. ;

Meijer, Adam ;

Kroes, Aloys C. M. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (10) :1435-1441

[6] Outcome of influenza infections in outpatients after allogeneic hematopoietic stem cell transplantation [J].

Khanna, N. ;

Steffen, I. ;

Studt, J. -D. ;

Schreiber, A. ;

Lehmann, T. ;

Weisser, M. ;

Flueckiger, U. ;

Gratwohl, A. ;

Halter, J. ;

Hirsch, H. H. .

TRANSPLANT INFECTIOUS DISEASE, 2009, 11 (02) :100-105

[7] The potential impact of neuraminidase inhibitor resistant influenza [J].

Lackenby, Angie ;

Thompson, Catherine I. ;

Democratis, Jane .

CURRENT OPINION IN INFECTIOUS DISEASES, 2008, 21 (06) :626-638

[8] Triple-Reassortant Swine Influenza A (H1) in Humans in the United States, 2005-2009 [J].

Shinde, Vivek ;

Bridges, Carolyn B. ;

Uyeki, Timothy M. ;

Shu, Bo ;

Balish, Amanda ;

Xu, Xiyan ;

Lindstrom, Stephen ;

Gubareva, Larisa V. ;

Deyde, Varough ;

Garten, Rebecca J. ;

Harris, Meghan ;

Gerber, Susan ;

Vagasky, Susan ;

Smith, Forrest ;

Pascoe, Neal ;

Martin, Karen ;

Dufficy, Deborah ;

Ritger, Kathy ;

Conover, Craig ;

Quinlisk, Patricia ;

Klimov, Alexander ;

Bresee, Joseph S. ;

Finelli, Lyn .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (25) :2616-2625

[9] Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza - A randomized controlled trial [J].

Treanor, JJ ;

Hayden, FG ;

Vrooman, PS ;

Barbarash, R ;

Bettis, R ;

Riff, D ;

Singh, S ;

Kinnersley, N ;

Ward, P ;

Mills, RG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (08) :1016-1024

← 1 →