Arginases in parasitic diseases

被引：117

作者：

Vincendeau, P ^{[1
]}

Gobert, AP ^{[1
]}

Daulouède, S ^{[1
]}

Moynet, D ^{[1
]}

Mossalayi, MD ^{[1
]}

机构：

[1] Univ Bordeaux 2, Equipe Accueil Immunol Mol & Parasitol, F-33076 Bordeaux, France

来源：

TRENDS IN PARASITOLOGY | 2003年 / 19卷 / 01期

关键词：

D O I：

10.1016/S1471-4922(02)00010-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Parasites have elaborated a variety of strategies for invading hosts and escaping immune responses. This article proposes that a common mechanism whereby different parasites escape nitric oxide (NO) toxicity is the activation of arginase. This leads to a depletion Of L-arginine (substrate of NO synthase, resulting in lower levels of cytotoxic NO) and increased production of polyamines (necessary for parasite growth and differentiation).

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页码：9 / 12

页数：4

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