Lipoxygenase inhibitors block CD95 ligand-mediated apoptosis of human malignant glioma cells

被引：40

作者：

Wagenknecht, B

Gulbins, E

Lang, F

Dichgans, J

Weller, M

机构：

[1] UNIV TUBINGEN,SCH MED,DEPT NEUROL,D-72076 TUBINGEN,GERMANY

[2] UNIV TUBINGEN,SCH MED,INST PHYSIOL,D-72076 TUBINGEN,GERMANY

来源：

FEBS LETTERS | 1997年 / 409卷 / 01期

关键词：

glioma; CD95; nordihydroguaretic acid; lipoxygenase; apoptosis; arachidonic acid;

D O I：

10.1016/S0014-5793(97)00468-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CD95 ligand is a cytotoxic cytokine that induces apoptosis. Here we report that CD95-mediated apoptosis of human malignant glioma cells is associated with arachidonic acid (AA) release. Inhibitors of phospholipase A(2), phospholipase C or diacylglycerol lipase have minor effects on AA release and fail to modulate apoptosis. Formation of two AA metabolites generated during CD95-dependent apoptosis is attenuated by the lipoxygenase inhibitor, nordihydroguaretic acid (NDGA), NDGA also blocks CD95 ligand-induced apoptosis, This effect is independent of antioxidant properties of NDGA. Lipoxygenase may thus play a critical role in CD95 ligand-induced apoptosis of human malignant glioma cells. (C) 1997 Federation of European Biochemical Societies.

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页码：17 / 23

页数：7

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