Synthesis and pharmacology of the 1'2'-dimethylheptyl-Delta(8)-THC isomers: Exceptionally potent cannabinoids

被引：26

作者：

Huffman, JW ^{[1
]}

Duncan, SG ^{[1
]}

Wiley, JL ^{[1
]}

Martin, BR ^{[1
]}

机构：

[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,RICHMOND,VA 23298

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(97)10086-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The four diastereomers of 1',2'-dimethylheptyl-Delta(8)-THC (2) have been synthesized. Pharmacology both in vitro and in vivo indicated that all four isomers were very potent cannabinoids. The 1'R,2'S and 1'S,2'R are considerably more potent than the other two isomers, and are among the most potent traditional cannabinoids known. (C) 1997 Elsevier Science Ltd.

引用

页码：2799 / 2804

页数：6

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