The RGM/DRAGON family of BMP co-receptors

被引：88

作者：

Corradini, Elena ^{[1
]}

Babitt, Jodie L. ^{[1
]}

Lin, Herbert Y. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Program Membrane Biol,Div Nephrol,Ctr Syst Biol, Boston, MA 02472 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 5-6期

基金：

美国国家卫生研究院;

关键词：

BMP; Receptors; RGM; DRAGON; HJV; REPULSIVE GUIDANCE MOLECULE; PROTEASE MATRIPTASE-2 TMPRSS6; GENE-EXPRESSION; HEPCIDIN EXPRESSION; SOLUBLE HEMOJUVELIN; NEOGENIN INTERACTS; IRON-METABOLISM; BONE; GROWTH; RGMA;

D O I：

10.1016/j.cytogfr.2009.10.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type If receptors. BMP ligands make use of a limited number of receptors, which in turn activate a common signal transduction cascade at the intracellular level. A complex regulatory network is required in order to activate the signaling cascade at proper times and locations, and to generate specific downstream effects in the appropriate cellular context. One such regulatory mechanism is the repulsive guidance molecule (RGM) family of BMP co-receptors. This article reviews the current knowledge regarding the structure, regulation, and function of RGMs, focusing on known and potential roles of RGMs in physiology and pathophysiology. (C) 2009 Elsevier Ltd. All rights reserved.

引用

收藏

页码：389 / 398

页数：10

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