Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together?

被引：233

作者：

Geiman, TM ^{[1
]}

Robertson, KD ^{[1
]}

机构：

[1] NCI, Epigenet Gene Regulat & Canc Sect, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2002年 / 87卷 / 02期

关键词：

epigenetics; DNA methylation; histone methylation; chromatin remodeling; gene expression;

D O I：

10.1002/jcb.10286

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA methylation is important in the control of gene transcription and chromatin structure. The complexities of this process are just beginning to be elucidated in relationship to other epigenetic mechanisms. Exciting new research in the areas of histone methylation and chromatin remodeling make it clear just how important the connections between these various mechanisms and DNA methylation are for the control of chromosome structure and gene expression. Emerging evidence suggests that chromatin remodeling enzymes and histone methylation are essential for proper DNA methylation patterns. Other histone modifications, such as acetylation and phosphorylation, in turn, affect histone methylation and histone methylation also appears to be highly reliant on chromatin remodeling enzymes. This review will summarize what is likely only the beginning of a flood of new information that will ultimately link all epigenetic modifications of the mammalian genome. A model will also be put forth to account for how chromatin modifications lead to genomic DNA methylation patterns.

引用

页码：117 / 125

页数：9

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