Characterization of calbindin-positive cones in primates

被引:30
作者
Chiquet, C
Dkhissi-Benyahya, O
Chounlamountri, N
Szel, A
Degrip, WJ
Cooper, HM
机构
[1] INSERM, U371, F-69675 Bron, France
[2] Univ Hosp Lyon, Dept Ophthalmol, F-69437 Lyon, France
[3] Semmelweis Univ, Dept Human Morphol, H-1094 Budapest, Hungary
[4] Univ Nijmegen, Dept Biochem, UMC 160, Nijmegen Ctr Mol Life Sci, Nijmegen, Netherlands
[5] Inst Fed Neurosci Lyon, F-69394 Lyon, France
关键词
retina; photoreceptor; calcium-binding protein; opsin; immunocytochemistry; prosimian;
D O I
10.1016/S0306-4522(02)00327-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The aim of this study is to characterize calbindin-positive photoreceptors and their opsin content in the retina of nocturnal prosimians (Microcebus murinus), New World monkeys (Callithrix jacchus), Old World monkeys (Macaca fascicularis), and humans. To identify the calbindin and opsin content of cones, combined multiple labeling with different fluorescent probes, antibodies directed against calbindin, short, and mid-long wavelength opsins, and lectin peanut agglutinin cytochemistry were used. With the exception of Microcebus, calbindin is present in the cones of all primates but is absent from rods. The distribution of calbindin is similar in human and macaque cones, with dense label in the inner segment, cell body, axon and cone pedicle. Cones in marmoset also show dense staining in the cell body, axon and pedicle but only light label in the inner segment. Primate cone outer segments do not contain calbindin. In the primates studied, three patterns of calbindin and opsin localization are observed. In macaque and marmoset all short and mid-long wavelength cones contain calbindin. In humans, all mid-long wavelength cones contain calbindin whereas all short wavelength cones are devoid of calbindin as confirmed by confocal microscopy. In the nocturnal prosimian Microcebus none of the mid-long or short wavelength cones contain calbindin. In addition to primates, calbindin is absent in cones of other nocturnal species but is present in cones of diurnal species suggesting a difference in the role of calbindin possibly related to the adaptational states or other photoreceptor properties. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1323 / 1333
页数:11
相关论文
共 68 条
  • [1] Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene
    Airaksinen, MS
    Eilers, J
    Garaschuk, O
    Thoenen, H
    Konnerth, A
    Meyer, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) : 1488 - 1493
  • [2] CALCIUM-BINDING PROTEINS IN THE NERVOUS-SYSTEM
    BAIMBRIDGE, KG
    CELIO, MR
    ROGERS, JH
    [J]. TRENDS IN NEUROSCIENCES, 1992, 15 (08) : 303 - 308
  • [3] BOWMAKER JK, 1991, J EXP BIOL, V156, P1
  • [4] Bumsted K, 1999, J COMP NEUROL, V403, P502
  • [5] DEMONASTERIO FM, 1985, INVEST OPHTH VIS SCI, V26, P289
  • [6] Short and mid-wavelength cone distribution in a nocturnal Strepsirrhine primate (Microcebus murinus)
    Dkhissi-Benyahya, O
    Szel, A
    Degrip, WJ
    Cooper, HM
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2001, 438 (04) : 490 - 504
  • [7] Ghosh KK, 1997, J COMP NEUROL, V379, P211
  • [8] Calretinin in the cat retina: Colocalizations with other calcium-binding proteins, GABA and glycine
    Goebel, DJ
    Pourcho, RG
    [J]. VISUAL NEUROSCIENCE, 1997, 14 (02) : 311 - 322
  • [9] IMMUNOCYTOCHEMICAL ANALYSIS OF BIPOLAR CELLS IN THE MACAQUE MONKEY RETINA
    GRUNERT, U
    MARTIN, PR
    WASSLE, H
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 348 (04) : 607 - 627
  • [10] CALBINDIN D-28K IMMUNOREACTIVITY OF HUMAN CONE CELLS VARIES WITH RETINAL POSITION
    HALEY, TL
    POCHET, R
    BAIZER, L
    BURTON, MD
    CRABB, JW
    PARMENTIER, M
    POLANS, AS
    [J]. VISUAL NEUROSCIENCE, 1995, 12 (02) : 301 - 307