Treatment of Patients With Atrial Fibrillation and Heart Failure With Reduced Ejection Fraction

被引：95

作者：

Verma, Atul ^{[1
]}

Kalman, Jonathan M. ^{[2
]}

Callans, David J. ^{[3
]}

机构：

[1] Univ Toronto, Dept Med & Surg, Div Cardiol, Southlake Reg Hlth Ctr, Toronto, ON M5S 1A1, Canada

[2] Univ Melbourne, Dept Med, Div Cardiol, Royal Melbourne Hosp, Melbourne, Vic 3010, Australia

[3] Univ Penn, Dept Med, Div Cardiovasc Dis, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

CIRCULATION | 2017年 / 135卷 / 16期

基金：

英国医学研究理事会;

关键词：

anti-arrhythmia agents; atrial fibrillation; catheter ablation; heart failure; VENTRICULAR SYSTOLIC DYSFUNCTION; PULMONARY-VEIN ISOLATION; STRICT RATE CONTROL; TERM-FOLLOW-UP; TACHYCARDIA-INDUCED CARDIOMYOPATHY; CATHETER ABLATION; PERICARDIAL FAT; SINUS RHYTHM; RISK-FACTOR; PROGNOSTIC-SIGNIFICANCE;

D O I：

10.1161/CIRCULATIONAHA.116.026054

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) frequently coexist, and each complicates the course and treatment of the other. Recent population-based studies have demonstrated that the 2 conditions together increase the risk of stroke, heart failure hospitalization, and all-cause mortality, especially soon after the clinical onset of AF. Guideline-directed pharmacological therapy for HFrEF is important; however, although there are various treatment modalities for AF, there is no clear consensus on how best to treat AF with concomitant HFrEF. This in-depth review discusses the available data for the treatment of AF in the setting of HFrEF, focuses on areas where more investigation is necessary, examines the clinical implications of randomized and observational clinical trials, and presents suggestions for individualized treatment strategies for specific patient groups.

引用

页码：1547 / 1563

页数：17

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