Magnetic nanoparticle relaxation measurement as a novel tool for in vivo diagnostics

被引：44

作者：

Romanus, E

Hückel, M

Gross, C

Prass, S

Weitschies, W

Bräuer, R

Weber, P

机构：

[1] Univ Jena, Inst Solid State Phys, D-07743 Jena, Germany

[2] Univ Greifswald, Inst Pharm, D-17487 Greifswald, Germany

[3] Univ Jena, Inst Pathol, D-07743 Jena, Germany

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2002年 / 252卷 / 1-3期

关键词：

relaxation measurements; SQUID; medical imaging; molecular imaging; magnetic nanoparticles; Neel relaxation;

D O I：

10.1016/S0304-8853(02)00645-5

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A measurement system for spatially resolved relaxation measurements of magnetic nanoparticles (MNP) was developed and tested in regard to its applicability for in vivo diagnostics. The system is based on SQUID sensors to detect the magnetic relaxation of MNP and has been optimized to operate in a laboratory environment without any magnetic shielding. Due to a dead time between switching off the magnetizing field and starting the measurement only bound MNP with appropriate Neel relaxation times contribute to the measured signal. The detection limit of the system for MNP was found to be 0.3 nmol (17 ng) Fe. First investigations on the detection of MNP in mice after intravenous injection showed that the determination of their relaxing magnetization might have the potential to be used as a novel tool for medical imaging. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：387 / 389

页数：3

共 5 条

[1] Comparison of size-selective techniques for the fractionation of magnetic fluids [J].