Several perinucleolar structures have been described in recent years. This review primarily summarizes recent studies regarding two of these structures, the perinucleolar compartment (PNC) and the Sam68 nuclear body (SNB). A number of studies have explored their ultrastructure and molecular components. Despite their different nuclear localizations, PNCs and SNBs share some common characteristics. They both are enriched with RNA binding proteins and nucleic acids and are predominantly localized to the periphery of the nucleolus. They are observed mostly in transformed cells, although prevalence differs among different cell types and cell lines. Their structural integrity is influenced by the transcriptional state of the cell. However, the functions of both the PNC and the SNB remain unknown. In addition to the PNC and SNB, a perinucleolar structure immunolabeled with an. antibody to hnRNPL will be discussed. (C) 2000 Academic Press.
机构:Univ Michigan, Sch Med, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
Chamberlain, JR
Lee, Y
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机构:Univ Michigan, Sch Med, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
Lee, Y
Lane, WS
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机构:Univ Michigan, Sch Med, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
Lane, WS
Engelke, DR
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Univ Michigan, Sch Med, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
机构:Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2, Canada
Chen, TP
Boisvert, FM
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Boisvert, FM
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Bazett-Jones, DP
Richard, S
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Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2, CanadaSir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2, Canada
机构:Univ Michigan, Sch Med, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
Chamberlain, JR
Lee, Y
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机构:Univ Michigan, Sch Med, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
Lee, Y
Lane, WS
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机构:Univ Michigan, Sch Med, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
Lane, WS
Engelke, DR
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Univ Michigan, Sch Med, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
机构:Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2, Canada
Chen, TP
Boisvert, FM
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机构:Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2, Canada
Boisvert, FM
Bazett-Jones, DP
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机构:Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2, Canada
Bazett-Jones, DP
Richard, S
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Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2, CanadaSir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2, Canada