Risk of thrombosis in patients with essential thrombocythemia and polycythemia vera according to JAK2 V617F mutation status

被引：104

作者：

Finazzi, Guido ^{[1
]}

Rambaldi, Alessandro ^{[1
]}

Guerini, Vittoria ^{[1
]}

Carobbo, Alessandra ^{[1
]}

Barbui, Tiziano ^{[1
]}

机构：

[1] Osped Riuniti Bergamo, UO Ematol, I-24128 Bergamo, Italy

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2007年 / 92卷 / 01期

关键词：

thrombosis; essential thrombocythemia; polycythemia vera; JAK2; mutation;

D O I：

10.3324/haematol.10634

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We compared the laboratory and clinical findings of 179 patients with essential thrombocythemia (ET) and 77 with polycythemia vera (PV) classified according to the presence of the JAK2 V617F mutation. A gradient between patients with JAK2 wildtype ET, JAK2 V617F ET and PV (all carrying the JAK2 mutation) was observed. The rate of thrombotic complications in JAK2-positive ET was significantly higher than in wild-type ET and not statistically different from that of PV patients.

引用

页码：135 / 136

页数：2

共 7 条

[1] Clinical implications of the JAK2 V617F mutation in essential thrombocythemia [J].

Antonioli, E ;

Guglielmelli, P ;

Pancrazzi, A ;

Bogani, C ;

Verrucci, M ;

Ponziani, V ;

Longo, G ;

Bosi, A ;

Vannucchi, AM .

LEUKEMIA, 2005, 19 (10) :1847-1849

[2] Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status:: a prospective study [J].

Campbell, PJ ;

Scott, LM ;

Buck, G ;

Wheatley, K ;

East, CL ;

Marsden, JT ;

Duffy, A ;

Boyd, EM ;

Bench, AJ ;

Scott, MA ;

Vassiliou, GS ;

Milligan, DW ;

Smith, SR ;

Erber, WN ;

Bareford, D ;

Wilkins, BS ;

Reilly, JT ;

Harrison, CN ;

Green, AR .

LANCET, 2005, 366 (9501) :1945-1953

[3] The presence of the JAK2 V617F mutation is associated with a higher haemoglobin and increased risk of thrombosis in essential thrombocythaemia [J].

Cheung, B ;

Radia, D ;

Pantelidis, P ;

Yadegarfar, G ;

Harrison, C .

BRITISH JOURNAL OF HAEMATOLOGY, 2006, 132 (02) :244-245

[4] Leucocyte alkaline phosphatase identifies terminally differentiated normal neutrophils and its lack in chronic myelogenous leukaemia is not dependent on p210 tyrosine kinase activity [J].

Dotti, G ;

Garattini, E ;

Borleri, G ;

Masuhara, K ;

Spinelli, O ;

Barbui, T ;

Rambaldi, A .

BRITISH JOURNAL OF HAEMATOLOGY, 1999, 105 (01) :163-172

[5]

Falanga A, 2005, BLOOD, V106, p114A

[6] Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia [J].

Harrison, CN ;

Campbell, PJ ;

Buck, G ;

Wheatley, K ;

East, CL ;

Bareford, D ;

Wilkins, BS ;

van der Walt, JD ;

Reilly, JT ;

Grigg, AP ;

Revell, P ;

Woodcock, BE ;

Green, AR ;

Pearson, TC ;

Conneally, E ;

Crawley, C ;

Cross, NCP ;

Hall, G ;

Hunt, B ;

Lucas, G ;

Ludlam, C ;

McMullin, MF ;

Oscier, D ;

Radia, D ;

Reilly, JT ;

Robinson, G ;

Culligan, DJ ;

Tighe, J ;

Watson, HG ;

Warren, AJ ;

Awaad, MO ;

Obeid, D ;

Cuthbert, RJG ;

Kyle, A ;

Chan-Lam, D ;

Paul, B ;

Cuthbert, RJG ;

McMullin, MF ;

Morris, TCM ;

Johnson, RJ ;

Fegan, C ;

Milligan, DW ;

Galloway, MJ ;

Williamson, PJ ;

Newton, LJ ;

Williams, AT ;

Abboudi, Z ;

Ryan, K ;

Lush, R ;

Blundell, E .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (01) :33-45

[7] JAK2V617F mutation in essential thrombocythaemia:: clinical associations and long-term prognostic relevance [J].

Wolanskyj, AP ;

Lasho, TL ;

Schwager, SM ;

McClure, RF ;

Wadleigh, M ;

Lee, SJ ;

Gilliland, DG ;

Tefferi, A .

BRITISH JOURNAL OF HAEMATOLOGY, 2005, 131 (02) :208-213

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