Vertebrate eye development as modeled in Drosophila

被引:145
作者
Wawersik, S [1 ]
Maas, RL
机构
[1] Harvard Univ, Sch Med, Grad Program Biol & Biomed Sci, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA
关键词
D O I
10.1093/hmg/9.6.917
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pax6, a member of the paired-box family of transcription factors, is critical for oculogenesis in both vertebrates and insects. Identification of potential vertebrate Pax6 targets has been guided by studies in Drosophila, where the Pax6 homologs eyeless (ey) and twin of eyeless (toy) function within a network of genes that synergistically pattern the developing fly eye. These targets, which share homology with the fly genes sine oculis, eyes absent and dachshund, exist in mice and humans as the Six, Eya and Dach gene families. Members of these gene families are present in the developing vertebrate eye, and preliminary studies suggest that they may function in a network analogous to that in the fly, Thus, despite radically different architecture, a similar molecular scaffold underlies both vertebrate and fly eye patterning, suggesting that the considerable power of Drosophila genetics can be harnessed to study mammalian ocular development.
引用
收藏
页码:917 / 925
页数:9
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