Immunopathology of schistosomiasis: a cautionary tale of mice and men

被引：89

作者：

Fallon, PG ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 01期

关键词：

D O I：

10.1016/S0167-5699(99)01551-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Murine experimental models have been used extensively to demonstrate that the specific dominance of a type 1 or type 2 cytokine response will influence the outcome of infection with a number of pathogens. Here, using a human helminth infection as an example, Padraic Fallon illustrates the problems of extrapolating from mouse to humans with respect to cytokine-associated immunopathology.

引用

页码：29 / 35

页数：7

共 57 条

[1] Functional diversity of helper T lymphocytes [J].

Abbas, AK ;

Murphy, KM ;

Sher, A .

NATURE, 1996, 383 (6603) :787-793

[2] Th1-Th2: reliable paradigm or dangerous dogma? [J].

Allen, JE ;

Maizels, RM .

IMMUNOLOGY TODAY, 1997, 18 (08) :387-392

[3] Evidence of a T helper type 2 activation in human schistosomiasis [J].

Araujo, MI ;

deJesus, AR ;

Bacellar, O ;

Sabin, E ;

Pearce, E ;

Carvalho, EM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (06) :1399-1403

[4]

Brunet LR, 1997, J IMMUNOL, V159, P777

[5] QUANTITATIVE COMPARISON OF INTENSITY OF SCHISTOSOMA-MANSONI INFECTIONS IN MAN AND EXPERIMENTAL ANIMALS [J].

CHEEVER, AW .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1969, 63 (06) :781-+

[6] IMMUNE-RESPONSES AND IMMUNOREGULATION IN RELATION TO HUMAN SCHISTOSOMIASIS IN EGYPT .3. IMMUNITY AND LONGITUDINAL-STUDIES OF INVITRO RESPONSIVENESS AFTER TREATMENT [J].

COLLEY, DG ;

BARSOUM, IS ;

DAHAWI, HSS ;

GAMIL, F ;

HABIB, M ;

ELALAMY, MA .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1986, 80 (06) :952-957

[7] Granulomatous inflammation and the transmission of infection: schistosomiasis - and TB too? [J].

Doenhoff, MJ .

IMMUNOLOGY TODAY, 1998, 19 (10) :462-467

[8] IDIOTYPIC SENSITIZATION INUTERO OF CHILDREN BORN TO MOTHERS WITH SCHISTOSOMIASIS OR CHAGAS-DISEASE [J].

ELOISANTOS, SM ;

NOVATOSILVA, E ;

MASELLI, VM ;

GAZZINELLI, G ;

COLLEY, DG ;

CORREAOLIVEIRA, R .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (03) :1028-1031

[9]

Estaquier J, 1997, EUR CYTOKINE NETW, V8, P153

[10]

Fallon PG, 1998, EUR J IMMUNOL, V28, P1408, DOI 10.1002/(SICI)1521-4141(199804)28:04&lt

← 1 2 3 4 5 6 →