Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants

被引：131

作者：

Bozza, S

Gaziano, R

Lipford, GB

Montagnoli, C

Bacci, A

Di Francesco, P

Kurup, VP

Wagner, H

Romani, L

机构：

[1] Univ Perugia, Dept Expt Med & Biochem Sci, Microbiol Sect, I-06122 Perugia, Italy

[2] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, Microbiol Sect, Rome, Italy

[3] R&D Coley Pharmaceut, Langenfield, Germany

[4] Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-8000 Munich, Germany

[5] Med Coll Wisconsin, Div Allergy Immunol, Milwaukee, WI 53226 USA

[6] Vet Affairs Med Ctr, Milwaukee, WI 53295 USA

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 13期

关键词：

fungi; dendritic cells; vaccination;

D O I：

10.1016/S1286-4579(02)00007-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a murine model of invasive pulmonary aspergillosis, dendritic cells (DCs) pulsed with Aspergillus antigens induced the activation of CD4(+) Th1 cells capable of conferring resistance to the infection. Here we show that the combined, local delivery of unmethylated CpG oligodeoxynucleotides (ODNs) and the Asp f 16 Aspergillus allergen resulted in the functional maturation and activation of airway DCs capable of inducing Th1 priming and resistance to the fungus. Therefore, ODNs act as a potent adjuvant for the vaccine-induced protection against the fungus by promoting dominant Th1 response to Aspergillus antigens and allergens. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：1281 / 1290

页数：10

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