Polysaccharide from Aspalathus linearis with strong anti-HIV activity

被引：31

作者：

Nakano, M ^{[1
]}

Itoh, Y ^{[1
]}

Mizuno, T ^{[1
]}

Nakashima, H ^{[1
]}

机构：

[1] YAMANASHI MED UNIV, DEPT MICROBIOL, YAMANASHI 40938, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 02期

关键词：

anti-HIV activity; polysaccharides; in vitro; alkaline extract; Aspalathus linearis;

D O I：

10.1271/bbb.61.267

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Polysaccharide that had been extracted with 1% sodium carbonate from Rooibos leaves (Aspalathus linearis) showed strong anti-HIV activity. Du-Zhong leaves also showed anti-HIV activity, although lower than the extract of Aspalathus linear is, but Japanese tea leaves and a hot water extract of Aspalathus linearis did not, The anti-HIV activity of the alkaline extract from Aspalathus linearis was recovered mainly in the 25-75% ethanol-precipitated fraction. The polysaccharide almost,completely inhibited the binding of HIV-1 to MT-4 cells, It is inferred from these results that the polysaccharide from Aspalathus linearis is involved in the mechanism for virus binding to T cells.

引用

页码：267 / 271

页数：5

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