Synthesis of metallo-beta-lactamase inhibitors

被引：24

作者：

Walter, MW

Adlington, RM

Baldwin, JE

Schofield, CJ

机构：

[1] DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] OXFORD CTR MOL SCI,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 21期

关键词：

D O I：

10.1016/S0040-4020(97)00404-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Amido trifluoromethyl alcohols and ketones were synthesised via two independent routes using the Ruppert Reagent (TMS-CF3) and shown to be inhibitors of metallo-beta-lactamases. (C) 1997 Elsevier Science Ltd.

引用

页码：7275 / 7290

页数：16

共 37 条

[1]

ABELES RH, 1986, TETRAHEDRON LETT, V27, P135

[2]

ABELES RH, 1985, BIOCHEMISTRY-US, V24, P1813

[3]

AMINO Y, 1989, CHEM PHARM BULL, V36, P4426

[4] PREPARATION OF TRIFLUOROMETHYL KETONES AND RELATED FLUORINATED KETONES [J].

BEGUE, JP ;

BONNETDELPON, D .

TETRAHEDRON, 1991, 47 (20-21) :3207-3258

[5] A REMARKABLY SIMPLE PREPARATION OF (TRIFLUOROMETHYL)CADMIUM AND (TRIFLUOROMETHYL) ZINC REAGENTS DIRECTLY FROM DIFLUORODIHALOMETHANES [J].

BURTON, DJ ;

WIEMERS, DM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (17) :5014-5015

[6] THE 3-D STRUCTURE OF A ZINC METALLO-BETA-LACTAMASE FROM BACILLUS-CEREUS REVEALS A NEW-TYPE OF PROTEIN FOLD [J].

CARFI, A ;

PARES, S ;

DUEE, E ;

GALLENI, M ;

DUEZ, C ;

FRERE, JM ;

DIDEBERG, O .

EMBO JOURNAL, 1995, 14 (20) :4914-4921

[7] CARBOXYPEPTIDASE-A [J].

CHRISTIANSON, DW ;

LIPSCOMB, WN .

ACCOUNTS OF CHEMICAL RESEARCH, 1989, 22 (02) :62-69

[8] A USEFUL 12-I-5 TRIACETOXYPERIODINANE (THE DESS-MARTIN PERIODINANE) FOR THE SELECTIVE OXIDATION OF PRIMARY OR SECONDARY ALCOHOLS AND A VARIETY OF RELATED 12-I-5 SPECIES [J].

DESS, DB ;

MARTIN, JC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (19) :7277-7287

[9] A METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF PEPTIDYL TRIFLUOROMETHYL KETONES [J].

EDWARDS, PD .

TETRAHEDRON LETTERS, 1992, 33 (30) :4279-4282

[10] ANGIOTENSIN-CONVERTING ENZYME - NEW CONCEPTS CONCERNING ITS BIOLOGICAL ROLE [J].

EHLERS, MRW ;

RIORDAN, JF .

BIOCHEMISTRY, 1989, 28 (13) :5311-5318

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