Reversible nonfluent aphasia and left frontal hypoperfusion during topiramate treatment

被引：8

作者：

Cappa, S. F.

Ortelli, P.

Garibotto, V.

Zamboni, M.

机构：

[1] Univ Vita Salute San Raffaele, Dept Neurosci, Milan, Italy

[2] Ist Sci San Raffaele, I-20132 Milan, Italy

[3] San Raffaele Turro Hosp, Dept Neurol, Milan, Italy

[4] Univ Milano Bicocca, Milan, Italy

[5] Ist Sci San Raffaele, Dept Nucl Med, Milan, Italy

来源：

EPILEPSY & BEHAVIOR | 2007年 / 10卷 / 01期

关键词：

epilepsy; topiramate; aphasia;

D O I：

10.1016/j.yebeh.2006.11.001

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We report the case of a patient with complex partial seizures who developed a nonfluent aphasia when topiramate was added to his therapy. This emergent adverse effect appeared to be reversible, as language performance improved after discontinuation of topiramate. Interictal SPECT performed when the patient was aphasic revealed a focal perfusion reduction in the left lateral and mesial frontal cortex, which was no longer evident at a follow-up study after language recovery. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：192 / 194

页数：3

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