Lung injury linked to etanercept therapy

被引:97
作者
Peno-Green, L
Lluberas, G
Kingsley, T
Brantley, S
机构
[1] WellStar Marietta Pulm Med, Marietta, GA USA
[2] Marietta Rheumatol Associates PC, Marietta, GA USA
[3] WellStar Pathol Dept, Marietta, GA USA
[4] Quantum Radiol NW, Marietta, GA USA
关键词
drug injury; etanercept; granulomatous inflammation; inflammatory lung disease; rheumatoid arthritis;
D O I
10.1378/chest.122.5.1858
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Etanercept is the first anticytokine drug approved to treat rheumatoid arthritis. Side effects are infrequent, the most common being local skin reactions, headaches, and upper respiratory tract symptoms. We report the first case of lung injury that occurred while receiving this agent. Biopsy specimens of lung and skin lesions demonstrated noneaseating granulomas associated with a microscopic particulate. Withdrawal of etanercept achieved clinical stabilization, and the addition of prednisone resulted in rapid improvement.
引用
收藏
页码:1858 / 1860
页数:3
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