Functional computed tomography in oncology

Functional Computed Tomography (CT) describes the use of existing technologies and conventional contrast agents to capture physiological parameters that reflect the vasculature within tumours and other tissues. The technique is readily incorporated into routine conventional CT examinations and, in tumours, the physiological parameters obtained provide an in-vivo marker of angiogenesis. As well as providing a research tool, functional CT has clinical applications in tumour diagnosis, staging, risk stratification and therapy monitoring, including the characterisation of pulmonary nodules, detection of occult hepatic metastases, grading of cerebral glioma and monitoring of anti-angiogenesis drugs. With the recent commercial availability of appropriate software and the development of multislice CT systems, functional CT is poised to make a significant impact upon the imaging of patients with cancer. (C) 2002 Elsevier Science Ltd. All rights reserved.