Delivery of Therapeutic RNAi by Nanovehicles

被引：27

作者：

Baigude, Huricha ^{[1
]}

Rana, Tariq M. ^{[1
]}

机构：

[1] Burnham Inst Med Res, Program RNA Biol, Sanford Childrens Hlth Res Ctr, La Jolla, CA 92037 USA

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 15期

关键词：

gene expression; nanoparticles; RNAi; siRNA delivery; therapeutic RNA; IN-VIVO DELIVERY; EFFICIENT SIRNA DELIVERY; SMALL INTERFERING RNA; DOUBLE-STRANDED-RNA; CHEMICAL-MODIFICATION; GENE DELIVERY; BRAIN CANCER; PLASMID DNA; POTENT; CELLS;

D O I：

10.1002/cbic.200900252

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Figure Presented) Designer packaging: Nanovehicles created from cationic polymers and anionic oligonucleotides through electrostatic interaction play a most important role in nonviral siRNA delivery. The type and content of amine in the polymer determine the hydrophobicity, surface charge, and particle size of resulting nanovehicle. Targeted delivery may be achieved by modifying the nanovehicle by coupling moieties that bind specific cell surface receptors. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2449 / 2454

页数：6

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