The Cid1 family of non-canonical poly(A) polymerases

被引：54

作者：

Stevenson, Abigail L. ^{[1
]}

Norbury, Chris J. ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

YEAST | 2006年 / 23卷 / 13期

基金：

英国医学研究理事会;

关键词：

poly(A) polymerase; Schizosaccharomyces pombe; RNA stability; translational control; Cid1; family; Trf4;

D O I：

10.1002/yea.1408

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyadenylation is an essential processing step for most eukaryotic mRNAs. In the nucleus, poly(A) polymerase adds poly(A) tails to mRNA 3' ends, contributing to their export, stability and translatability. Recently, a novel class of non-canonical poly(A) polymerases was discovered in yeast, worms and vertebrates. Different members of the Cid1 family, named after its founding member in the fission yeast Schizosaccharomyces pombe, are localized in the nucleus and the cytoplasm and are thought to target specific RNAs for polyadenylation. Polyadenylation of a target RNA by a Cid1-like poly(A) polymerase can lead to its degradation or stabilization, depending on the enzyme involved. Cid1-like proteins have important roles in diverse biological processes, including RNA surveillance pathways, DNA integrity checkpoint responses and RNAi-dependent heterochromatin formation. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：991 / 1000

页数：10

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