Biophysics of sphingolipids I.: Membrane properties of sphingosine, ceramides and other simple sphingolipids

被引：211

作者：

Goni, Felix M.

Alonso, Alicia

机构：

[1] Univ Basque Country, EHU, CSIC, Ctr Mixto,Unidad Biofis, E-48080 Bilbao, Spain

[2] Univ Basque Country, Dept Bioquim, E-48080 Bilbao, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2006年 / 1758卷 / 12期

关键词：

sphingolipid; ceramide; sphingosine; sphingosine-1-phosphate; ceramide-1-phosphate; membrane domain; membrane order; membrane permeability; membrane fusion; flip-flop;

D O I：

10.1016/j.bbamem.2006.09.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some of the simplest sphingolipids, namely sphingosine, ceramide, some closely related molecules (eicosasphingosine, phytosphingosine), and their phosphorylated compounds (sphingosine-1-phosphate, ceramide-1-phosphate), are potent metabolic regulators. Each of these lipids modifies in marked and specific ways the physical properties of the cell membranes, in what can be the basis for some of their physiological actions. This paper reviews the mechanisms by which these sphingolipid signals, sphingosine and ceramide in particular, are able to modify the properties of cell membranes. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1902 / 1921

页数：20

共 148 条

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