Similar biochemical signatures and prion protein genotypes in atypical scrapie and Nor98 cases, France and Norway

被引：84

作者：

Arsac, Jean-Noel

Andreoletti, Olivier

Bilheude, Jean-Marc

Lacroux, Caroline

Benestad, Sylvie L.

Baron, Thierry

机构：

[1] AFSSA Lyon, Unit ATNC, F-69364 Lyon 07, France

[2] Ecole Natl Vet Toulouse, Toulouse, France

[3] Bio Rad, Marnes La Coquette, France

[4] Natl Vet Inst, Oslo, Norway

来源：

EMERGING INFECTIOUS DISEASES | 2007年 / 13卷 / 01期

关键词：

D O I：

10.3201/eid1301.060393

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Isolates of atypical scrapie recently identified in sheep and goats in France were compared with Nor98 isolates reported in Norway. Western blot methods for characterization of the protease-resistant prion protein showed that all these isolates shared a unique biochemical signature: 5 groups of bands, including a characteristic band of apparent low molecular weight (11 kDa). This pattern could originate from the presence of 3 different protease cleavage products, including the 11 kDa most likely cleaved at both N- and C-sides of the protein. Genetic data, which strongly suggested the higher susceptibility of AHQ and AF(141)RQ animals in French cases, resembled earlier data from Nor98 scrapie.

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页码：58 / 65

页数：8

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