Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes

被引：72

作者：

Kurek, Anna ^{[1
]}

Grudniak, Anna M. ^{[1
]}

Szwed, Magdalena ^{[1
]}

Klicka, Anna ^{[1
]}

Samluk, Lukasz ^{[1
]}

Wolska, Krystyna I. ^{[1
]}

Janiszowska, Wirginia ^{[2
]}

Popowska, Magdalena ^{[3
]}

机构：

[1] Univ Warsaw, Inst Microbiol, Dept Bacterial Genet, PL-02096 Warsaw, Poland

[2] Univ Warsaw, Inst Biochem, Dept Plant Biochem, PL-02096 Warsaw, Poland

[3] Univ Warsaw, Inst Microbiol, Dept Appl Microbiol, PL-02096 Warsaw, Poland

来源：

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY | 2010年 / 97卷 / 01期

关键词：

Autolysis; Listeria monocytogenes; Oleanolic acid; Peptidoglycan; Ursolic acid; ANTIBIOTIC-RESISTANCE; MUREIN; ANTIBACTERIAL; VIABILITY; VIRULENCE; TURNOVER; GENE;

D O I：

10.1007/s10482-009-9388-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The plant pentacyclic triterpenoids, oleanolic and ursolic acids, inhibit the growth and survival of many bacteria, particularly Gram-positive species, including pathogenic ones. The effect of these compounds on the facultative human pathogen Listeria monocytogenes was examined. Both acids affected cell morphology and enhanced autolysis of the bacterial cells. Autolysis of isolated cell walls was inhibited by oleanolic acid, but the inhibitory activity of ursolic acid was less pronounced. Both compounds inhibited peptidoglycan turnover and quantitatively affected the profile of muropeptides obtained after digestion of peptidoglycan with mutanolysin. These results suggest that peptidoglycan metabolism is a cellular target of oleanolic and ursolic acids.

引用

页码：61 / 68

页数：8

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