Characteristics of clinical Helicobacter pylori strains from Ecuador

被引：17

作者：

Debets-Ossenkopp, YJ

Reyes, G

Mulder, J

aan de Stegge, BM

Peters, JTAM

Savelkoul, PHM

Tanca, J

Peña, AS

Vandenbroucke-Grauls, CMJE

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Clin Microbiol & Infect Control, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Gastroenterol, NL-1081 HV Amsterdam, Netherlands

[3] Univ Catolica, Dept Mol Biol, Guayaquil, Ecuador

[4] SOLCA Hosp, Dept Gastroenterol, Guayaquil, Ecuador

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 51卷 / 01期

关键词：

Helicobacter pylori; Ecuador; antibiotic resistance; typing; virulence factors;

D O I：

10.1093/jac/dkg023

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In Ecuador, Helicobacter pylori infections are highly prevalent. A total of 42 H. pylori clinical isolates from 86 patients attending the outpatient clinic of the gastroenterology department of the university hospital of Guayaquil in Ecuador were characterized. Their susceptibility, and cagA and vacA status were determined. Resistance to metronidazole and clarithromycin was found in 80.9% and 9.5% of strains, respectively. Neither amoxicillin- nor tetracycline-resistant strains were found. The most prevalent genotype was the cagA(+), vacA s1b,m1 type. This genotype was associated with gastric cancer and peptic ulcer. Typing by random amplified polymorphic DNA showed no genetic relationship among the strains.

引用

页码：141 / 145

页数：5

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