Physiological gain leads to high ISI variability in a simple model of a cortical regular spiking cell

被引:195
作者
Troyer, TW
Miller, KD
机构
[1] UNIV CALIF SAN FRANCISCO,SLOAN CTR THEORET NEUROBIOL,DEPT PHYSIOL,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,SLOAN CTR THEORET NEUROBIOL,DEPT OTOLARYNGOL,SAN FRANCISCO,CA 94143
关键词
D O I
10.1162/neco.1997.9.5.971
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
To understand the interspike interval (ISI) variability displayed by visual cortical neurons (Softky & Koch, 1993), it is critical to examine the dynamics of their neuronal integration, as well as the variability in their synaptic input current. Most previous models have focused on the latter factor. We match a simple integrate-and-fire model to the experimentally measured integrative properties of cortical regular spiking cells (McCormick, Conners, Lighthall, & Prince, 1985). After setting RC parameters, the postspike voltage reset is set to match experimental measurements of neuronal gain (obtained from in vitro plots of firing frequency versus injected current). Examination of the resulting model leads to an intuitive picture of neuronal integration that unifies the seemingly contradictory 1/root N and random walk pictures that have previously been proposed. When ISIs are dominated by postspike recovery, 1/root N arguments hold and spiking is regular; after the ''memory'' of the last spike becomes negligible, spike threshold crossing is caused by input variance around a steady state and spiking is Poisson. In integrate-and-fire neurons matched to cortical cell physiology, steady-state behavior is predominant, and ISIs are highly variable at all physiological firing rates and for a wide range of inhibitory and excitatory inputs.
引用
收藏
页码:971 / 983
页数:13
相关论文
共 16 条
[1]  
ABELES M, 1982, ISRAEL J MED SCI, V18, P83
[2]  
Abeles M., 1991, CORTICONICS
[3]   Precisely correlated firing in cells of the lateral geniculate nucleus [J].
Alonso, JM ;
Usrey, WM ;
Reid, RC .
NATURE, 1996, 383 (6603) :815-819
[4]  
BELL AJ, 1995, INC9502 U CAL SAN DI
[5]   RANDOM WALK MODELS FOR SPIKE ACTIVITY OF SINGLE NEURON [J].
GERSTEIN, GL ;
MANDELBROT, B .
BIOPHYSICAL JOURNAL, 1964, 4 (1P1) :41-&
[6]   Chaos and synchrony in a model of a hypercolumn in visual cortex [J].
Hansel, D ;
Sompolinsky, H .
JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 1996, 3 (01) :7-34
[7]   Comparison of discharge variability in vitro and in vivo in cat visual cortex neurons [J].
Holt, GR ;
Softky, WR ;
Koch, C ;
Douglas, RJ .
JOURNAL OF NEUROPHYSIOLOGY, 1996, 75 (05) :1806-1814
[8]   COMPARATIVE ELECTROPHYSIOLOGY OF PYRAMIDAL AND SPARSELY SPINY STELLATE NEURONS OF THE NEOCORTEX [J].
MCCORMICK, DA ;
CONNORS, BW ;
LIGHTHALL, JW ;
PRINCE, DA .
JOURNAL OF NEUROPHYSIOLOGY, 1985, 54 (04) :782-806
[9]   ORIENTATION SELECTIVITY OF CORTICAL-NEURONS DURING INTRACELLULAR BLOCKADE OF INHIBITION [J].
NELSON, S ;
TOTH, L ;
SHETH, B ;
SUR, M .
SCIENCE, 1994, 265 (5173) :774-777
[10]  
Shadlen Michael N., 1994, Current Opinion in Neurobiology, V4, P569, DOI 10.1016/0959-4388(94)90059-0