Efficient asymmetric synthesis of 1-alk-2-yne-1,4-diols

被引：27

作者：

Diez, RS

Adger, B

Carreira, EM

机构：

[1] ETH Honggerberg, Organ Chem Lab, CH-8093 Zurich, Switzerland

[2] Univ Burgos, Fac Ciencias, Area Quim Organ, Burgos 09001, Spain

[3] Synetix, Cambridge CB2 5JE, England

来源：

TETRAHEDRON | 2002年 / 58卷 / 41期

关键词：

1,4-diols; asymmetric synthesis; optically active compounds;

D O I：

10.1016/S0040-4020(02)00985-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe an expeditious process that provides ready access to symmetrical and unsymmetrical optically active bispropargylic 1,4-diols. The method employs the use of a recent method we have developed involving terminal acetylenes, Zn(OTf)(2), amine base, and N-methyl ephedrine. The 1,4-diol products should serve as useful building blocks for asymmetric synthesis. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：8341 / 8344

页数：4

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