Paclitaxel and docetaxel combinations in non-small cell lung cancer

被引:26
作者
Belani, CP
机构
[1] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Dept Med, Div Med Oncol, Pittsburgh, PA USA
关键词
carboplatin; cisplatin; docetaxel; non-small cell lung cancer; paclitaxel; taxanes;
D O I
10.1378/chest.117.4_suppl_1.144S
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Paclitaxel, the first of the taxanes, has exhibited unique and encouraging single-agent activity in the treatment of non-small cell lung cancer (NSCLC). Yet, with single-agent response rates approaching 25%, it was logical to examine the impact of paclitaxel in combination chemotherapy regimens. In trials evaluating the activity of paclitaxel in combination with one of the platinum compounds, cisplatin or carboplatin, response rates have ranged from 35 to > 50% and were significantly better than response rates observed with etoposide/cisplatin, the previous standard regimen for treatment of NSCLC. Docetaxel is a newer taxane that also has exhibited notable single-agent activity and response rates ranging from 20 to 50% when combined with cisplatin. Future research will look to refine the use of taxane combinations in NSCLC and to examine the potential of these unique and promising drugs when combined with newer agents that are active against this disease.
引用
收藏
页码:144S / 151S
页数:8
相关论文
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