Diastereospecific synthesis of ketooxindoles. Potential intermediates for the synthesis of alstonisine as well as for Voachalotine related oxindole alkaloids

被引：23

作者：

Yu, P ^{[1
]}

Cook, JM ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT CHEM,MILWAUKEE,WI 53201

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(97)10420-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method has been developed to convert N-a-H tetracyclicketone Ia into the two corresponding oxindoles[C(7)] diastereospecifically. Treatment of the N-a-H, N-b-benzyl tetracyclicketone la with t-BuOCl provided diastereomer 2a (related to Voacanga oxindoles), whereas the same process with N-b-H (Ib) or N-b-benzoyl (Ic) substituted analogs funished the diastereomers 2b and 2c (related to alstonisine), respectively. (C) 1997 Elsevier Science Ltd.

引用

页码：8799 / 8802

页数：4

共 14 条

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