Distribution, Metabolism and Toxic Effects of Beta-Cypermethrin in Lizards (Eremias argus) Following Oral Administration

被引：39

作者：

Chen, Li ^{[1
,2
]}

Xu, Peng ^{[3
]}

Diao, Jinling ^{[2
]}

Di, Shanshan ^{[1
,2
]}

Li, Ruiting ^{[2
]}

Zhou, Zhiqiang ^{[1
,2
]}

机构：

[1] Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Yuanmingyuan West Rd 2, Beijing 100193, Peoples R China

[2] China Agr Univ, Dept Appl Chem, Yuanmingyuan West Rd 2, Beijing 100193, Peoples R China

[3] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, Shuangqing RD 18, Beijing 100085, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2016年 / 306卷

基金：

中国国家自然科学基金;

关键词：

Beta-cypermethrin; Degradation; Organ coefficient; Histopathology; TRANS-CYPERMETHRIN; CIS-CYPERMETHRIN; ALPHA-CYPERMETHRIN; RAINBOW-TROUT; REPTILES; PESTICIDES; BIOTRANSFORMATION; BIOACCUMULATION; PYRETHROIDS; PERMETHRIN;

D O I：

10.1016/j.jhazmat.2015.11.053

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

Beta-cypermethrin (BCYP), a synthetic pyrethriod (PYR) pesticide which is a mixture of the alpha- and theta- cypermethrin, have been reported various toxicological profiles to non-target organisms. But little is known about assimilation, accumulation and toxic effects of BCYP in reptiles. The present study firstly elucidated absorption, tissue distribution, excretion of BCYP in Eremias argus. Treated group were administered orally with BCYP 20 mg/kg body weight (bw) dissolved in corn oil. Neurotoxicity was observed at 24 h after gavage, and the poisoning symptom ameliorated at 72 h. The changes of BCYP concentration depended on degradation time and tissues. Lizards had a strong capacity to eliminate BCYP with different tissue distribution. The tissues concentration of BCYP from high to low were intestine, stomach, heart, kidney, blood, lung, liver and brain. Bimodal phenomena were observed in lung, liver and kidney. These results may be due to the activities of enzymes, circadian rhythm, and enterohepatic circulation in lizards. Based on the results of organ coefficient and histopathology analysis in liver, the liver was confirmed as the main target organ. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：87 / 94

页数：8

共 51 条

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