Analysis of terfenadine in human plasma using microbore high-performance liquid chromatography electrospray ionisation mass spectrometry

被引：12

作者：

Adams, DA ^{[1
]}

Murray, S ^{[1
]}

Clifford, CP ^{[1
]}

Rendell, NB ^{[1
]}

Davies, DS ^{[1
]}

Taylor, GW ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH,DEPT CLIN PHARMACOL,LONDON W12 0NN,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY B | 1997年 / 693卷 / 02期

关键词：

terfenadine;

D O I：

10.1016/S0378-4347(97)00083-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An assay based on combined microbore high-performance liquid chromatography-positive ion electrospray ionisation mass spectrometry with selected ion recording has been developed for the measurement of the antihistamine drug terfenadine in human plasma. A deuterated analogue of terfenadine was synthesised for use as an internal standard and extraction of terfenadine was carried out on C-18 solid phase extraction columns. The limit of detection of terfenadine in plasma is 0.1 ng/ml and the intra-assay coefficient of variation at 1 ng/ml is 10.1%. Plasma concentrations of terfenadine measured in six normal subjects following a 120 mg oral dose are reported.

引用

页码：345 / 351

页数：7

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