Double nucleophilic addition. A new one-pot synthesis of 2-alkyl- and 2-phenyl-5-hydrazinopyridine from pyridine

被引：19

作者：

Zhang, LH ^{[1
]}

Tan, ZL ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Chem Dev, Ridgefield, CT 06877 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)00340-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of 2-alkyl- and 2-phenyl-5-hydrazinopyridine has been developed. Nucleophilic addition on pyridine by alkyl or phenyl lithium reagents generated a 2-substituted dihydropyridine anion that reacts with di-t-butyl azodicarboxylate to form 2,5-disubstituted dihydropyridine. Conversion of the dihydropyridines to pyridines was achieved by a mild air oxidation. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3025 / 3028

页数：4

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