IL-28, IL-29 and their class II cytokine receptor IL-28R

被引：1396

作者：

Sheppard, P ^{[1
]}

Kindsvogel, W ^{[1
]}

Xu, WF ^{[1
]}

Henderson, K ^{[1
]}

Schlutsmeyer, S ^{[1
]}

Whitmore, TE ^{[1
]}

Kuestner, R ^{[1
]}

Garrigues, U ^{[1
]}

Birks, C ^{[1
]}

Roraback, J ^{[1
]}

Ostrander, C ^{[1
]}

Dong, D ^{[1
]}

Shin, J ^{[1
]}

Presnell, S ^{[1
]}

Fox, B ^{[1
]}

Haldeman, B ^{[1
]}

Cooper, E ^{[1
]}

Taft, D ^{[1
]}

Gilbert, T ^{[1
]}

Grant, FJ ^{[1
]}

Tackett, M ^{[1
]}

Krivan, W ^{[1
]}

McKnight, G ^{[1
]}

Clegg, C ^{[1
]}

Foster, D ^{[1
]}

Klucher, KM ^{[1
]}

机构：

[1] Zymogenet Inc, Seattle, WA 98102 USA

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 01期

关键词：

D O I：

10.1038/ni873

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL- 10 family. We found that like type I IFNs, IL- 28 and IL- 29 were induced by viral infection and showed antiviral activity. However, IL- 28 and IL- 29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.

引用

页码：63 / 68

页数：6

共 35 条

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