IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies

被引：72

作者：

Ida, A

Tsuji, Y

Muranaka, J

Kanazawa, R

Nakata, Y

Adachi, S

Okamura, H

Koyama, K

机构：

[1] Hyogo Coll Med, Dept Obstet & Gynecol, Nishinomiya, Hyogo 6638501, Japan

[2] Hyogo Coll Med, Inst Adv Med Sci, Host Def Lab, Nishinomiya, Hyogo 6638501, Japan

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2000年 / 47卷 / 01期

关键词：

cytokine; IL-18; pregnancy; Th1; Th2;

D O I：

10.1016/S0165-0378(00)00058-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum interleukin-18 (IL-18) levels were measured in women in different trimesters of pregnancy, in labour, puerperium and in various complicated pregnancies. There was a significant elevation of IL-18 levels in pregnant sera from the first trimester until the onset of labour. Once labour began, IL-18 levels increased further and remained until at least the third day of puerperium. The high levels of IL-18 in sera were also observed in various complicated pregnancies, such as premature rupture of membranes (PROM), acute fatty liver of pregnancy and fetal growth restriction. IL-18 is likely to play a role in pregnancy. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：65 / 74

页数：10

共 17 条

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