Neural cell adhesion molecule-mediated neurite outgrowth is repressed by overexpression of HES-1

被引：11

作者：

Jessen, U ^{[1
]}

Novitskaya, V ^{[1
]}

Walmod, PS ^{[1
]}

Berezin, V ^{[1
]}

Bock, E ^{[1
]}

机构：

[1] Univ Copenhagen, Inst Mol Pathol, Prot Lab, DK-2200 Copenhagen N, Denmark

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2003年 / 71卷 / 01期

关键词：

NCAM; HES-1; neurite outgrowth; transcription factor;

D O I：

10.1002/jnr.10433

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neural cell adhesion molecule (NCAM) stimulates neurite outgrowth by activating intracellular signaling cascades. We investigated the role of the transcriptional repressor HES-1 in NCAM-dependent neurite outgrowth by estimating neurite extension from PC12-E2 cells grown in coculture with NCAM-negative or NCAM-positive fibroblasts. PC12-E2 cells were transiently transfected with an expression plasmid encoding HES-1. We found that expression of HES-1 inhibited NCAM-dependent neurite outgrowth. Treatment with arachidonic acid (an important messenger in NCAM-dependent signaling) restored NCAM-induced neurite outgrowth inhibited by HES-1. These results suggest that HES-1 is a regulator of intracellular signal transduction stimulated by cell adhesion molecules involved in neurite outgrowth. (C) 2002 Wiley-Liss, Inc.

引用

页码：1 / 6

页数：6

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