AMPK as a Therapeutic Target for Treating Metabolic Diseases

被引：529

作者：

Day, Emily A. ^{[1
]}

Ford, Rebecca J. ^{[1
]}

Steinberg, Gregory R. ^{[1
,2
]}

机构：

[1] McMaster Univ, Dept Med, 1280 Main St West, Hamilton, ON, Canada

[2] McMaster Univ, Dept Biochem & Biomed Sci, 1280 Main St West, Hamilton, ON, Canada

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2017年 / 28卷 / 08期

关键词：

ACTIVATED PROTEIN-KINASE; ENDOPLASMIC-RETICULUM STRESS; INDUCED INSULIN-RESISTANCE; SKELETAL-MUSCLE; MACROPHAGE POLARIZATION; ENERGY SENSOR; SERINE; 491; PHOSPHORYLATION; INFLAMMATION; AUTOPHAGY;

D O I：

10.1016/j.tem.2017.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic pathways and may have therapeutic importance for treating obesity, insulin resistance, type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). Given the ubiquitous expression of AMPK, it has been a challenge to evaluate which tissue types may be most beneficially poised for mediating the positive metabolic effects of AMPK-centered treatments. In this review we evaluate the metabolic phenotypes of transgenic mouse models in which AMPK expression and function have been manipulated, and the impact this has on controlling lipid metabolism, glucose homeostasis, and inflammation. This information may be useful for guiding the development of AMPK-targeted therapeutics to treat chronic metabolic diseases.

引用

页码：545 / 560

页数：16

共 64 条

[1] Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery [J].

Albers, Peter H. ;

Bojsen-Moller, Kirstine N. ;

Dirksen, Carsten ;

Serup, Annette K. ;

Kristensen, Dorte E. ;

Frystyk, Jan ;

Clausen, Trine R. ;

Kiens, Bente ;

Richter, Erik A. ;

Madsbad, Sten ;

Wojtaszewski, Jorgen F. P. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2015, 309 (05) :R510-R524

[2] The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells [J].

Alvarez-Guardia, David ;

Palomer, Xavier ;

Coll, Teresa ;

Davidson, Mercy M. ;

Chan, Tung O. ;

Feldman, Arthur M. ;

Laguna, Juan C. ;

Vazquez-Carrera, Manuel .

CARDIOVASCULAR RESEARCH, 2010, 87 (03) :449-458

[3] Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress [J].

Antonucci, Laura ;

Fagman, Johan B. ;

Kim, Ju Youn ;

Todoric, Jelena ;

Gukovsky, Ilya ;

Mackey, Mason ;

Ellisman, Mark H. ;

Karin, Michael .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (45) :E6166-E6174

[4] Mechanisms underlying the resistance to diet-induced obesity in germ-free mice [J].

Backhed, Fredrik ;

Manchester, Jill K. ;

Semenkovich, Clay F. ;

Gordon, Jeffrey I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :979-984

[5] De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells [J].

Berod, Luciana ;

Friedrich, Christin ;

Nandan, Amrita ;

Freitag, Jenny ;

Hagemann, Stefanie ;

Harmrolfs, Kirsten ;

Sandouk, Aline ;

Hesse, Christina ;

Castro, Carla N. ;

Baehres, Heike ;

Tschirner, Sarah K. ;

Gorinski, Nataliya ;

Gohmert, Melanie ;

Mayer, Christian T. ;

Huehn, Jochen ;

Ponimaskin, Evgeni ;

Abraham, Wolf-Rainer ;

Mueller, Rolf ;

Lochner, Matthias ;

Sparwasser, Tim .

NATURE MEDICINE, 2014, 20 (11) :1327-1333

[6] AMPK-independent inhibition of human macrophage ER stress response by AICAR [J].

Boss, Marcel ;

Newbatt, Yvette ;

Gupta, Sahil ;

Collins, Ian ;

Bruene, Bernhard ;

Namgaladze, Dmitry .

SCIENTIFIC REPORTS, 2016, 6

[7] RETRACTED: Ablation of Adenosine Monophosphate-Activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification In Vivo (Retracted article. See vol. 131, 2022) [J].

Cai, Zhejun ;

Ding, Ye ;

Zhang, Miao ;

Lu, Qiulun ;

Wu, Shengnan ;

Zhu, Huaiping ;

Song, Ping ;

Zou, Ming-Hui .

CIRCULATION RESEARCH, 2016, 119 (03) :422-+

[8] Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status [J].

Cameron, Amy R. ;

Morrison, Vicky L. ;

Levin, Daniel ;

Mohan, Mohapradeep ;

Forteath, Calum ;

Beall, Craig ;

McNeilly, Alison D. ;

Balfour, David J. K. ;

Savinko, Terhi ;

Wong, Aaron K. F. ;

Viollet, Benoit ;

Sakamoto, Kei ;

Fagerholm, Susanna C. ;

Foretz, Marc ;

Lang, Chim C. ;

Rena, Graham .

CIRCULATION RESEARCH, 2016, 119 (05) :652-665

[9] Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK) [J].

Cao, Jia ;

Meng, Shumei ;

Chang, Evan ;

Beckwith-Fickas, Katherine ;

Xiong, Lishou ;

Cole, Robert N. ;

Radovick, Sally ;

Wondisford, Fredric E. ;

He, Ling .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (30) :20435-20446

[10] Myeloid Deletion of α1AMPK Exacerbates Atherosclerosis in LDL Receptor Knockout (LDLRKO) Mice [J].

Cao, Qiang ;

Cui, Xin ;

Wu, Rui ;

Zha, Lin ;

Wang, Xianfeng ;

Parks, John S. ;

Yu, Liqing ;

Shi, Hang ;

Xue, Bingzhong .

DIABETES, 2016, 65 (06) :1565-1576

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